CovidV1, Main, Exploration, bibRecord, 001256

Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions

Identifieur interne : 001256 ( Main/Exploration ); précédent : 001255; suivant : 001257

Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions

Auteurs : Orlando Ghirardi [Italie] ; Roberto Cozzolino [Italie] ; Donatella Guaraldi [Italie] ; Alessandro Giuliani [Italie]

Source :

Experimental Gerontology [ 0531-5565 ] ; 1995.

RBID : ISTEX:8A93D726250563D7313145B30E96BBB617E33E6C

English descriptors

Teeft :
- Animal models, Average values, Biological material, Birth dates, Causal factors, Charles river, Component scores, Different populations, Different strains, Disease processes, Factor loadings, Fischer, Fischer rats, Gompertz, Gompertz equation, Gompertz survival function, Iffa credo, Inbred, Individual groups, Initial mortality rate, Interindividual variability, Interquartile range, Laboratory animals, Life expectancy, Life span, Longevity, Longevity curves, Longevity data, Longevity parameters, Male fischer, Male rats, Nongenetic variability, Outbred rats, Parameter, Phenotypic variability, Present study, Principal component analysis, Rat, Same discrepancy, Same strain, Second year, Significant correlation, Significant differences, Statistical analysis, Study period, Survival curve, Survival curves, Survival data, Survival parameters, Variability.

Abstract

Abstract: The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to highlight some limitations of the classical Gompertzian approach.

Url:

https://api.istex.fr/ark:/67375/6H6-P1RNVGHQ-4/fulltext.pdf

DOI: 10.1016/0531-5565(95)00002-X

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000684
to stream Istex, to step Curation: 000664
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to stream Main, to step Curation: 001256

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to highlight some limitations of the classical Gompertzian approach.</div>
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Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions

Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri